What amino acids that would form a strong metal binding site for Cu+ at pH 7?
Amino acids that have side chains incorporating functional
groups that would most likely form a strong metal binding site for the
soft Cu+ ion surrounded by a protein at physiological pH?
Answers:
Cu+ has a plus charge, so you want an amino acid to donate its electron to the Cu+ , so the amino tart needs to act resembling a base. Any amino acid near a base side chain should work, resembling Arginine (Arg) or histidine (His) or Lysine (Lys). So you are looking for an amine functional group because amines are the most common organic basis.
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groups that would most likely form a strong metal binding site for the
soft Cu+ ion surrounded by a protein at physiological pH?
Answers:
Cu+ has a plus charge, so you want an amino acid to donate its electron to the Cu+ , so the amino tart needs to act resembling a base. Any amino acid near a base side chain should work, resembling Arginine (Arg) or histidine (His) or Lysine (Lys). So you are looking for an amine functional group because amines are the most common organic basis.
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